UJI AKTIVITAS ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN TEMBELEKAN (Lantana camara L.) TERHADAP MENCIT PUTIH JANTAN TERINDUKSI ALOKSAN

  • Eka Setia Rini Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman
  • Rudi Kartika Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman
  • Rahmat Gunawan Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Abstract

Phytochemical screening has been conducted on the ethanol extract of tembelekan leaves (Lantana camara Linn) which showed the presence of alkaloids, flavanoids, steroids, triterpenoids and phenolic. Testing antihyperglicemic activity of ethanol extract tembelekan leaves conducted experiments in the laboratory with each dose 14 mg/kg BW, 28 mg/kg BW and 56 mg/kg BW given orally in male mice induced by alloxan. Measurement of blood glucose levels done on day 0, 4, 8, 14 and 18 by using glucometer and glucose test strips. The decrease in blood glucose levels is 56,89 % with ethanol extract tembelekan leaves dose 56 mg/kg BW. The results showed that there is decrease in blood glucose because given ethanol extract tembelekan leaves.

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References

[1] Ajeng, P. A. 2013. Isolasi dan Uji Aktivitas Senyawa Metabolit Sekunder dari Ekstrak Fraksi n-Heksan Daun Tumbuhan Tembelekan
(Lantana camara L.). Skripsi. Fakultas Farmasi Universitas Mulawarman. Samarinda.
[2] Arjadi, F dan Susatyo, P. 2010. Regenerasi Sel Pulau Langerhans Pada Tikus Putih (Ratus norvegicus) Diabetes Diberi Rebusan Daging
Mahkota Dewa (Phaleria macrocarp (scheff.)Boerl.). vol.2. No. 2.
[3] Benerjee M and Bhonde R.R. 2003. Islet Genertion From Intra Isletr Precursor Cells of Diabetic Pancreas: In Vitro Studies Depicting in Vivo Differentiation, J. Pancreas (4): 137-145.
[4] Fauziah dkk. 2014. The Effect Of Curry Leaves (Murayya koenigii L.) on Blood Glucose Levels In Alloxan Diabetic Mice (mus musculus). Vol 14. No 1. ISSN 1141-8513.
[5] Gaw, A. dkk. 2011. Biokimia Klinis Teks Bergambar Edisi 4. Jakarta: Penerbit Buku Kedokteran EGC.
[6] Hii C.S. and Howell S.L. 1985. Effects on Flavanoids on Insulin Secretion and 4Sca2+ Handling in Rat Islet of Langerhans, J. Endrocinol. 107: 18.
[7] Rahim, A. 2014. Analisis Fitokimia Tumbuhan Obat di Kabupaten Bualemo. Jurusan Kimia Fakultas Matamatika dan IPA. Universitas Negeri Gorontalo.
[8] Suyono, S. 2009. Kecenderungan Peningkatan Jumlah Penyandang Diabetes. Jakarta: Fakultas Kedokteran Universitas Indonesia Press.
[9] Utami, P. 2003. Tanaman Obat Untuk Mengatasi Diabetes Mellitus. Agromedia Pustaka: Jakarta.
Published
2016-09-29
How to Cite
RINI, Eka Setia; KARTIKA, Rudi; GUNAWAN, Rahmat. UJI AKTIVITAS ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN TEMBELEKAN (Lantana camara L.) TERHADAP MENCIT PUTIH JANTAN TERINDUKSI ALOKSAN. JURNAL ATOMIK, [S.l.], v. 1, n. 2, sep. 2016. ISSN 2549-0052. Available at: <http://jurnal.kimia.fmipa.unmul.ac.id/index.php/JA/article/view/328>. Date accessed: 25 apr. 2024.
Section
Artikel

Keywords

Tembelekan leaves (Lantana camara Linn), antihyperglycemic, phytochemical screening