TY - JOUR AU - Lelita, Resy AU - Gunawan, Rahmat AU - Astuti, Winni TI - STUDI DOCKING MOLEKULAR SENYAWA KUERSETIN, KALKON DAN TURUNANNYA SEBAGAI INHIBITOR SEL KANKER PAYUDARA MC-7 (MICHIGAN CANCER FOUNDATION-7) JF - JURNAL KIMIA MULAWARMAN KW - N2 - Molecular Docking studies Quercetin, Chalcone and its derivate inhibitor to breast cancer cells MCF-7 (Michigan Cancer Foundation-7) have been done. The results showed that the docking energies after the process of binding on mode 1 of four compounds Quersetin -7.4 Kcal/mol, 2-(3,4-dihidroksifenil)-5,7-dihidroksi-3-metoksi-3,4-dihidro-2H-1-benzopyran-4-on -6.8 Kcal/mol, Chalcone -6.7 Kcal/mol and 3-(2,4-dihidroksifenil)-1-fenilpropan-1-on -6.6 Kcal/mol. Quercetin formed hydrogen bondings with amino acid  of Aspartic Acid 61, Arginine 65, Arginine 68, Fenilalanin 71 and Serin 75. , 2-(3,4-dihidroksifenil)-5,7-dihidroksi-3-metoksi-3,4-dihidro-2H-1-benzopyran-4-on formed hydrogen bondings with amino acid of Alanin 59, Asparagine 102 dan Arginine 105. Chalcone formed hydrogen bondings with amino acid of Glitamic Acid 94 and 3-(2,4-dihidroksifenil)-1-fenilpropan-1-on formed hydrogen bondings with amino acid of Tyrosine 67. Quercetin is as potential than anticancer drug than chalcone, -(3,4-dihidroksifenil)-5,7-dihidroksi-3-metoksi-3,4-dihidro-2H-1-benzopyran-4-on and 3-(2,4-dihidroksifenil)-1-fenilpropan-1-on. UR - http://jurnal.kimia.fmipa.unmul.ac.id/index.php/JKM/article/view/460