SYNTHESIS AND PRELIMINARY EVALUATION OF 3,3’-DIHYDROXY-4,4’-DIMETHOXYDIBENZYLIDENEACETONE AS SUNSCREEN AND ANTIOXIDANT ACTIVE COMPOUND

  • Harizal Harizal Universitas Esa Unggul
  • Ariyo Prabowo Hidayanto Program Studi Bioteknologi, Fakultas Ilmu-ilmu Kesehatan, Universitas Esa Unggul, Jakarta, Indonesia
  • Nindya Wulan Sari Laboratorium Terpadu Fakultas Ilmu-ilmu Kesehatan, Universitas Esa Unggul, Jakarta, Indonesia

Abstract

Synthesis and preliminary evaluation of 3,3’-dihydroxy-4,4’-dimethoxydibenzylidenacetone (DDB) as sunscreen and antioxidant have been successfully conducted. The compound was prepared throught acid catalyzed condensation reaction between vanillin and aceton using saturated HCl solution in glacial acetic acid. Pre-evaluation of sunscreen active compound candidate was performed by determining electronic absorbance profile, lamdamax, e, lamda c, UVA/UVB ratio, and photostability. While antioxidant activity test was performed using DPPH radical scavenger method. Based on the results obtained, the compound obtained has very good protective effect in UVA regions with high antioxidant activity.

Keyword
vanillin, dibenzylidenacetone, sunscreen, antioxidant

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Author Biography

Harizal Harizal, Universitas Esa Unggul

Lecture in Pharmacy Department, Universitas Esa Unggul

References

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Published
2018-11-29
How to Cite
HARIZAL, Harizal; HIDAYANTO, Ariyo Prabowo; SARI, Nindya Wulan. SYNTHESIS AND PRELIMINARY EVALUATION OF 3,3’-DIHYDROXY-4,4’-DIMETHOXYDIBENZYLIDENEACETONE AS SUNSCREEN AND ANTIOXIDANT ACTIVE COMPOUND. JURNAL KIMIA MULAWARMAN, [S.l.], v. 16, n. 1, p. 49-59, nov. 2018. ISSN 2476-9258. Available at: <http://jurnal.kimia.fmipa.unmul.ac.id/index.php/JKM/article/view/665>. Date accessed: 21 feb. 2019. doi: https://doi.org/10.30872/jkm.v16i1.665.
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Artikel