Acute Toxicity Test Of P-Metoxicynamic Acid Synthetic From Ethyl P-Methysicynamate

  • Sara Nurmala Universitas Pakuan
  • Indah Zahara Program Studi Farmasi Stikes Prima Indonesia Bekasi 17610

Abstract

Kencur (Kaempferia galanga L.) is a plant that grows in Indonesia and is often used as a traditional spice. The main content of Kencur is ethyl p-methoxycinamic has a mild level of toxicity. Hydrolysis results from Ethyl p-methoxycinamic namely p-methoxycinamic acid have been widely studied as having antibacterial activity against S. aureus with MIC of 125 ppm. P-methoxycinamic acid has anti-inflammatory activity, topical anti-inflammatory power of 8.7% p-methoxycinamic acid based on molar equality with 1% Na-diclofenac. Cinnamic acid compounds have greater potential as an inhibitor of cervical cancer cells compared to methyl cinnamon because they have more hydrogen bonds. Hydrolysis of ethyl p-methoxycinamic to p-methoxycinamic acid has been carried out, then identification tests have been carried out covering the melting distance obtained values ​​of 172–173ºC. The results of TLC analysis with the mobile phase of methanol: acetone (2: 1) p-methoxycinamic acid compound gave an Rf value of: 0.67. The results of infrared spectrum analysis of hydrolysis compounds provide information on the presence of specific functional groups, namely carbonyl groups of acids (C = O) which are shown by the absorption band at wave number 1690.49 cm-1. Hydrogen bonding in carboxylic acid dimers weakens the C = O bond, resulting in absorption at lower wave numbers. In this spectrum CO groups of acids are shown at absorption of 1029.92 cm-1, aromatic C = C groups are shown by uptake at wave numbers 1602.74 cm-1 and 1627.81 cm-1, while bands at wave number 828.37 cm-1 indicates the presence of para-substituted aromatic nuclei. Acute toxicity test of p-methoxycinamic acid compound which was carried out in a span of 24 hours showed that p-methoxycinamic acid had a moderate level of toxicity.

Keyword
P-methoxycinamic acid, Acute Toxicity Test, Kencur

Downloads

Download data is not yet available.

References

[1] Alamsyah, F. 2002. Uji Fototoksisitas Senyawa Etilp-Metoksisinamat hasil Isolasi dari Rimpang Kencur (Kaempferia galangal L) terhadap larva Artemia salina Leach dengan Radiasi UV 254 nm dan 356 nm. diakses di halaman http://digilib.ubaya.ac.id/pustaka.php/150768 Pada tanggal 21 Januari 2020.
[2] Arkan, H. 2017. Sintesis Asam p-metoksisinamat dari rimpang kencur (Kaempferia galangal L) dan uji aktivitas antibakterinya. diakses di halaman https://akademik.unsoed.ac.id/index.php?r=artikelilmiah/view&id=17746 Pada tanggal 21 Januari 2020.
[3] Fareza, M. S., Rehana, R., Nuryanti., Mujahidin, D. 2017. Transformasi Etil p-Metoksisinamat Menjadi Asam p-metoksisinamat dari Kencur (Kaempheria Galanga L.) Beserta Uji Aktivitas Antibakterinya. Jurnal Penelitian Kimia, Vol.13 No.2 hal. 176-190.
[4] Ferwadi, S., Gunawan, R., Astuti, W. 2017. Studi Docking Molekular Senyawa Asam Sinamat Dan Derivatnya Sebagai Inhibitor Protein 1J4X Pada Sel Kanker Serviks. Jurnal Kimia Mulawarman, Vol.14 No.2.
[5] Mustapa, M. A., Tutoli, T. S., Mooduto, A. M., 2018. Uji Toksisitas Akut Yang Diukur Dengan Penentuan Ld50 Ekstrak Etanol Bunga Cengkeh (Syzygium aromaticum L.) Terhadap Mencit (Mus musculus) Menggunakan Metode Thompson-Weil. Jurnal Sains dan Teknologi, Universitas Negeri Manado. Vol.1 No.1 hal. 105-117.
[6] Nurmala, S. 2017. Uji Toksisitas Akut Senyawa Etil p-Metoksisinamat yang diisolasi dari rimpang kencur (Kaempferia galangal L). Jurnal Fitofarmaka Vol.7 No. 2 hal. 30-33.
[7] Pudjiastuti., Sa’roni., Nuratmi, B. 2001. Uji Toksisitas Akut (LD50) dan Antipiretik Infus Rimpang Zingiber Purpureum ROXB (Bengle) pada Hewan Percobaan. Media Penelitian dan Pengembangan Kesehatan Vol. 11 No.3.
[8] Soeratri, W., Erawati, T., Rohmatika,D., Rosita, N. 2014. Penentuan Dosis Asam p-metoksisinamat (APMS)Sebagai Antiinflamasi Topikal dan Studi Penetrasi APMS Melalui Kulit Tikus dengan dan Tanpa Stratum Korneum. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, Vol.1 No.1 hal. 28-30.
[9] Thompson dan Weil CS. 1952. Tables for Convenient Calculation of Median EffectiveDose (LD50 or ED50) And Instructions in Their Use. Biometrics 8:249-263.
[10] Tjitrosoepomo, 2005. Taksonomi Tumbuhan Obat-Obatan. Universitas Gadjah Mada Press: Yogyakarta.
[11] Wirasuta I Made Agus G dan Niruri Rasmaya, 2016. Toksikologi Umum. Buku Ajar. Jurusan Farmasi Fakultas Matematika Dan Ilmu Pengetahuan Alam: Universitas Udayana.
[12] Wiryowidagdo, 2005. Kimia & Farmakologi Bahan Alam Edisi 2. Buku Kedokteran EGC: Jakarta.
Published
2022-05-30
How to Cite
NURMALA, Sara; ZAHARA, Indah. Acute Toxicity Test Of P-Metoxicynamic Acid Synthetic From Ethyl P-Methysicynamate. JURNAL KIMIA MULAWARMAN, [S.l.], v. 19, n. 2, p. 76-80, may 2022. ISSN 2476-9258. Available at: <http://jurnal.kimia.fmipa.unmul.ac.id/index.php/JKM/article/view/901>. Date accessed: 29 mar. 2024. doi: https://doi.org/10.30872/jkm.v19i2.901.
Section
Artikel