STUDI POTENSI SENYAWA DERIVATIF FLAVONOID DARI TANAMAN GENUS MACARANGA TERHADAP PROTEIN E6 HPV DENGAN METODE DOCKING MOLECULAR
Abstract
Interaction study of active compounds of a medicinal plant with cervical cancer cells using the Docking Molecular (In Silico) method. In this research design the active compound sophoraflavanone B, 5,7,3 ', 4'-tetrahidroxy-3,6-diprenylflavone, apigenin and quercetin are first calculated using a quantum approach based on SCF method set 3-21G to obtain a stable compound form and has the lowest energy. Stable compounds interact with cervical cancer cells obtained from protein bank data (GDP) that have been prepared previously to obtain an inhibitory energy value, the number of hydrogen bonds and other factors that influence a Docking Molecular calculation. The interaction of compounds 5,7,3 ', 4'-tetrahydroxy-3,6-diprenylflavone against E6-HPV of 4 hydrogen bonds with a distance of 2.7-3.23 Å.
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References
[2] Lala, Z., Wagey, F., Lohe, M. 2016. Evaluasi Penanganan Kanker Serviks di RSUP Prof. Dr. R. D. Kandou periode 1 Januari 2013 – 31 Desember 2014. Jurnal e-clinic (eCl), Volume 4(1), Januari-Juni 2016. Manado: Universitas Sam Ratulangi.
[3] Ernawati, T., Fairusi, D. 2013. Sintesis Fenil sinamat dan 4-Fenilkromanon-2-on dan Uji Sitotoksisitas Terhadap Sel Kanker Serviks HeLa. Tangerang: Universitas Indonesia
[4]Taylor L, 2012. Annona muricata. Herbal secret of the Rainforest: The Healing Power of over 50 Medicinal Plants you Should Know About.http://www.raintree.com/graviola.htm#.VOFqZixNfMw, diakses tanggal 20 Juni 2014.
[5] M. Valiev, E.J. Bylaska, N. Govind, K. Kowalski, T.P. Straatsma, H.J.J. Van Dam, D. Wang, J. Nieplocha, E. Apra, T.L. Windus, W.A. De Jong. 2010. NWChem: A Comprehensive and Scalable Open-Source Solution For Large Scale Molecular Simulations. www.nwchem-sw.org/index.php/Main_page.
[6] Andersen, M., Markham, K.R. 2006. Flavonoids. Taylor & Francis Group. New York.
[7] Mujahid dan Bunyamin. 2014. Uji Proliverasi dan Uji Apotoksis Ganoderma lucidum (Curtis) P. Karst sebagai Antikanker Serviks. Purwekorto: Universitas Muhammadiyah.
[8] Darmawan, A. 2015. A New Flavonoid derivative as cytotoxic compound isolated from ethyl acetate extract of Macaranga gigantifolia Merr. Leaves. Procedia Chemistry : Elsevier Vol 16 hal. 53-57
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