Formulation And Physical Stability Test Of Mother-In-Law’s Tongue Leaves Extract Lotion As An Antioxidant
Abstract
Mother-in-law's tongue leaves (Sansevieria trifasciata P.) is a plant of the genus Sansevieria with flavonoid compound namely trifasciatin, as an antioxidant. Antioxidants can be used in cosmetics to protect the skin from free radicals. The purpose of this research was to analyze antioxidant activity of mother-in-law's tongue leaves extract and to obtain the best lotion formulation with various concentrations. Samples were extracted using 96% ethanol solvent with maceration method. Antioxidant activity was tested using DPPH method and intensity was measured at λ=517 nm by UV-Vis spectrophotometer. The IC50 value=49.72 ppm indicates a very strong antioxidant activity, compared to vitamin C=4.01 ppm (very strong). Extract was formulated in lotion with various concentrations of 0.5%, 1%, 3%, 6% and the comparison was vitamin C with same concentration as well as base without the addition of active substances. Based on observations for 4 weeks, 3% extract lotion is the best formulation. The organoleptic test results showed no change in shape, texture, color, odor, and pH so lotion was stable. In addition, the value of viscosity, spreadability, adhesion, irritation test according to established standards also has an antioxidant value 99.72% (strong category). So effective to ward off free radicals on the skin.
Keyword
Antioxidant, Free Radical, Lotion, Mother-in-law's tongue, Sansevieria trifasciata
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References
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[37] Purwaningsih, Sri, Ella Salamah, Tika A. Budiarti. (2014). Formulasi Skin Lotion Dengan Penambahan Karagenan dan Antioksidan Alami Dari Rhizophora Mucronata Lamk. Jurnal Akuatika, 5(1), 55-62.
[38] Jellinek, J. Stephan D. R. (1970). Formulation and Function of Cosmetics, Translated by GL Fenton. John Willey & Sons Inc.
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[41] Mardikasari, S. A., A. N. T. A. Mallarangeng, W. O. S. Zubaydah, dan E. Juswita. (2017). Uji Stabilitas Lotion dari Ekstrak Etanol Daun Jambu Biji (Psidium Guajava L.). Jurnal Farmasi, Sains, dan Kesehatan, 3(2), 28-32.
[42] Standar Nasional Indonesia 164399. (1996). Sediaan Tabir Surya. Badan Standarisasi Nasional.
[43] Shovyana, H., & Zulkarnain, A. (2013). Aktivitas Amilum Bengkuang (Pachyrrizus Erosus L. Urban) Sebagai Tabir Surya Pada Mencit dan Pengaruh Kenaikan Kadarnya Terhadap Viskositas Sediaan. Trad. Med. J, 18(1), 1-8.
[2] Andarina, Rosi, and Tantawi Djauhari. (2017). Antioksidan Dalam Dermatologi. JKK, 4(1), 39-48.
[3] Santoso, Umar. (2021). Antioksidan Pangan. Yogyakarta: UGM Press.
[4] Poljšak, Borut, and Raja Dahmane. (2012). Free Radicals and Extrinsic Skin Aging. Dermatol Res Pract. doi: 10.1155/2012/135206.
[5] Kesuma, Yenrina. (2015). Antioksidan Alami dan Sintetik. Padang: Andalas University Press.
[6] Rahimah, R. 2015. Karakteristik Simplisia dan Skrinning Fitokimia serta Uji Aktivitas Antioksidan dan Ekstrak Etanol Daun Lidah Mertua (Sanseviera trifasciata var. laurentii). Medan: Universitas Sumatera Utara.
[7] Tchegnitegni, Billy T., Rémy B. Teponno, Chiaki Tanaka, Adeyemi F. Gabriel, Léon A. Tapondjou, and Tomofumi Miyamoto. (2015). Sappanin-Type Homoisoflavonoids from Sansevieria Trifasciata Prain. Phytochemistry Letters, 12, 262–66. doi: 10.1016/j.phytol.2015.04.017.
[8] Abdullah, Angelina, Mauhibah Yumna, Rita Arbianti, Tania Surya Utami, Heri Hermansyah, and Sri Ningsih. (2018). Flavonoid Isolation and Identification of Mother-in-Law’s Tongue Leaves (Sansevieria Trifasciata) and the Inhibitory Activities to Xanthine Oxidase Enzyme. E3S Web of Conferences, 67. doi: 10.1051/e3sconf/20186703011.
[9] Ervianingsih, Izal Zahran, Hurria Hurria, and Novita Imeldha. (2020). Uji Efektivitas Ekstrak Lidah Mertua (Sansevieria Trifasciata) Untuk Menyembuhkan Luka Bakar Pada Hewan Coba Kelinci (Oryctolagus Cuniculus). Jurnal Farmasi Indonesia, 17(1), 1–7. doi: 10.31001/jfi.v17i1.752.
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[11] Tchegnitegni, Billy T., Rémy B. Teponno, Kristina Jenett-Siems, Matthias F. Melzig, Tomofumi Miyamoto, and Léon A. Tapondjou. (2017). A Dihydrochalcone Derivative and Further Steroidal Saponins from Sansevieria Trifasciata Prain. Zeitschrift Fur Naturforschung - Section C Journal of Biosciences, 72(11–12), 477-82. doi: 10.1515/znc-2017-0027.
[12] Thu, Zaw Min, Ko Ko Myo, Hnin Thanda Aung, Chabaco Armijos, and Giovanni Vidari. (2020). Flavonoids and Stilbenoids of the Genera Dracaena and Sansevieria: Structures and Bioactivities. Molecules, 25(11). doi: 10.3390/molecules25112608.
[13] Lombogia, Brily, Fona Budiarso, and Widdhi Bodhi. (2016). Uji Daya Hambat Ekstrak Daun Lidah Mertua (Sansevieriae Trifasciata Folium) Terhadap Pertumbuhan Bakteri Escherichia Coli dan Streptococcus Sp. Jurnal E-Biomedik, 4(1). doi: 10.35790/ebm.4.1.2016.12230.
[14] Ong, Mei Gee, Siti Nur Aishah Mat Yusuf, and Vuanghao Lim. (2016). Pharmacognostic and Antioxidant Properties of Dracaena Sanderiana Leaves. Antioxidants, 5(3), 1–9. doi: 10.3390/antiox5030028.
[15] A, Tanveer, Devendra Singh N, and Faheem Khan M. (2017). Phytochemical Analysis, Total Phenolic Content, Antioxidant and Antidiabetic Activity of Sansevieria Cylindrica Leaves Extract. Herbal Medicine: Open Access, 03(02). doi: 10.21767/2472-0151.100026.
[16] Yumna, Mauhibah, Angelina, Abdullah, Rita Arbianti, Tania Surya Utami, and Heri Hermansyah. (2018). Effect of Mother-in-Law’s Tongue Leaves (Sansevieria Trifasciata) Extract’s Solvent Polarity on Anti-Diabetic Activity through in Vitro α-Glucosidase Enzyme Inhibition Test. E3S Web of Conferences 67, 0-4. doi: 10.1051/e3sconf/20186703003.
[17] Anggia, Vivi, Lusi Putri Dwita, and Istikomah Istikomah. (2019). Antioxidant and Alpha-Amylase Inhibitory Study of Sansevieria Trifasciata Prain. Leaves Extract. Pharmaciana 9(1), 41. doi: 10.12928/pharmaciana.v9i1.11902.
[18] Nurhasnawati, Henny, Reksi Sundu, Sapri, Risa Supriningrum, Harlinda Kuspradini, and Enos Tangke Arung. (2019). Antioxidant Activity, Total Phenolic and Flavonoid Content of Several Indigenous Species of Ferns in East Kalimantan, Indonesia. Biodiversitas, 20(2), 576–80. doi: 10.13057/BIODIV/D200238.
[19] A.T. Adhityaxena, A. Megantika, R. Arbianti, T. S. Utami, and H. Hermansyah. (2020). Extraction of Flavonoid from Mother-In-Laws Tongue Leaves (Sansevieria Trifasciata) by Ultrasound Assisted Enzymatic Extraction and Its Inhibition Test. AIP Conference Proceedings, 2255:040008.
[20] Deepa, P., P. K. Kaleena, K. Valtivittan, and K. C. P. Girish. (2011). Phytochemical Screening and Antimicrobial Activity of Sansevieria Roxburghiana Schult and Suhult. F. Middle-East J. Sci. Res,10, 512–18.
[21] Roy, Jimuty, Mohammad Kuddus, Bilkis Begum, and Hasan Choudhury. (2012). Evaluation of Analgesic, Cytotoxic and Antioxidant Activities of Sansevieria Roxburghiana Schult. and Schult. f. Asian Pacific Journal of Tropical Biomedicine 2(2 SUPPL.), S723–26. doi: 10.1016/S2221-1691(12)60303-7.
[22] Shukla, Abha, Swati Vats, and R. K. Shukla. (2015). Phytochemical Screening, Proximate Analysis and Antioxidant Activity of Dracaena Reflexa Lam. Leaves. Indian Journal of Pharmaceutical Sciences 77(5), 640–44. doi: 10.4103/0250-474X.169035.
[23] Dewatisari, Whika Febria, Leni Rumiyanti, dan Ismi Rakhmawati. (2018). Rendemen dan Skrining Fitokimia pada Ekstrak Daun Sanseviera Sp. Jurnal Penelitian Pertanian Terapan, 17(3), 197. doi: 10.25181/jppt.v17i3.336.
[24] Costa, Raquel, and Lúcia Santos. (2017). Delivery Systems for Cosmetics from Manufacturing to the Skin of Natural Antioxidants. Powder Technology, 322, 402–16. doi: 10.1016/j.powtec.2017.07.086.
[25] Pinky, Sagorika Sing, Sirajum Monira, Md Akbar Hossain, and Amir Hossain. (2020). Antioxidant, Anti-Inflammatory, Cytotoxic and Analgesic Activities of Sensevieria Trifasciata. Bangladesh Pharmaceutical Journal, 23(2), 195–200. doi: 10.3329/bpj.v23i2.48341.
[26] Mayawati, Eva, Liza Pratiwi, and Bambang Wijianto. (2014). Uji Efektivitas Antioksidan Metanol Buah Pepaya (Carica Papaya L.) Dalam Formulasi Krim Terhadap DPPH (2,2-Diphenyl-1-Picrylhydrazil). Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN, 1(1).
[27] Sulastri, Evi, Y. Yusriadi, and Dinda Rahmiyati. (2016). Pengaruh Pati Pragelatinasi Beras Hitam Sebagai Bahan Pembentuk Gel Tehadap Mutu Fisik Sediaan Masker Gel Peel Off. Jurnal Pharmascience 03(02), 69-79.
[28] Hasan, Hamsidar, dan Dewi Moo. (2014). Senyawa Kimia dan Uji Efektivitas Ekstrak Tanaman Kayu Kuning (Arcangelisia Flava L) Dalam Upaya Pengembangan Sebagai Bahan Obat Herbal. Universitas Gorontalo.
[29] Yuhernita, and Juniarti. (2011). Analisis Senyawa Metabolit Sekunder Dari Ekstrak Metanol Daun Surian yang Berpotensi Sebagai Antioksdan. Jakarta: Fakultas Kedokteran Universitas Yarsi.
[30] Hardiyanti Febby. (2015). Pemanfaatan Aktivitas Antioksidan Ekstrak Daun Kelor (Moringa Oleifera) Dalam Sediaan Hand and Body Cream. Jakarta: Universitas Islam Negeri Syarif Hidayatullah.
[31] Andayani, Regina, dan Yovita Lisawati. (2008). Penentuan Aktivitas Antioksidan, Kadar Fenolat Total dan Likopen Pada Buah Tomat (Solanum Lycopersicum L). Jurnal Sains dan Teknologi Farmasi, 13(1), 31–37.
[32] Lung, Jackie Kang Sing, dan Dika Pramita Destiani. (2018). Uji Aktivitas Antioksidan Vitamin A, C, E dengan Metode DPPH. Farmaka, 15(1), 53-62.
[33] Lachman, Leon. (1994). Teori dan Praktek Farmasi Industri III (Ed Suyatmi). Jakarta: Universitas Indonesia Press.
[34] Mappa, Tiara, Hosea Jaya Edy, and Novel Kojong. (2013). Formulasi Gel Ekstrak Daun Sasaladahan (Peperomia Pellucida (L.) H.B.K) dan Uji Efektivitasnya Terhadap Luka Bakar Pada Kelinci (Oryctolagus Cuniculus). Pharmacon 2(2), 49-56.
[35] Sulastri, Evi, dan Cristadeolia Oktaviani. (2015). Formulasi Mikroemulsi Ekstrak Bawang Hutan dan Uji Aktivitas Antioksidan. Jurnal Pharmascience Research Article, 2(2), 1-14.
[36] Depkes RI. (1979). Farmakope Indonesia (Edisi III). Jakarta: Departemen Kesehatan RI.
[37] Purwaningsih, Sri, Ella Salamah, Tika A. Budiarti. (2014). Formulasi Skin Lotion Dengan Penambahan Karagenan dan Antioksidan Alami Dari Rhizophora Mucronata Lamk. Jurnal Akuatika, 5(1), 55-62.
[38] Jellinek, J. Stephan D. R. (1970). Formulation and Function of Cosmetics, Translated by GL Fenton. John Willey & Sons Inc.
[39] Voigt Rudolf. (1995). Buku Pelajaran Teknologi Farmasi. Yogyakarta; UGM Press.
[40] Ansel, H. C. (2005). Pengantar Bentuk Sediaan Farmasi. Jakarta: UI Press.
[41] Mardikasari, S. A., A. N. T. A. Mallarangeng, W. O. S. Zubaydah, dan E. Juswita. (2017). Uji Stabilitas Lotion dari Ekstrak Etanol Daun Jambu Biji (Psidium Guajava L.). Jurnal Farmasi, Sains, dan Kesehatan, 3(2), 28-32.
[42] Standar Nasional Indonesia 164399. (1996). Sediaan Tabir Surya. Badan Standarisasi Nasional.
[43] Shovyana, H., & Zulkarnain, A. (2013). Aktivitas Amilum Bengkuang (Pachyrrizus Erosus L. Urban) Sebagai Tabir Surya Pada Mencit dan Pengaruh Kenaikan Kadarnya Terhadap Viskositas Sediaan. Trad. Med. J, 18(1), 1-8.
Published
2023-11-26
How to Cite
YUNINGSIH, Lela Mukmilah et al.
Formulation And Physical Stability Test Of Mother-In-Law’s Tongue Leaves Extract Lotion As An Antioxidant.
JURNAL KIMIA MULAWARMAN, [S.l.], v. 21, n. 1, p. 24-37, nov. 2023.
ISSN 2476-9258.
Available at: <http://jurnal.kimia.fmipa.unmul.ac.id/index.php/JKM/article/view/1235>. Date accessed: 04 may 2024.
doi: https://doi.org/10.30872/jkm.v21i1.1235.
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