Pengaruh Pemberian Ekstrak Etanol Daun Kecapi (Sandoricum koetjape (Burm.f.) Merr.) Terhadap Penurunan Kadar Kolesterol Total pada Mencit Jantan (Mus musculus)

  • Rudi Kartika Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Abstract

The research about utilization of ethanol extract form leafkecapi (Sandoricum koetjape (Burm.f.)Merr.)has been done, it proved could decrease  total cholesterol levels in male mice (Mus musculus). In this research sample macerated with ethanol 96% and then concentrated by rotary evaporator, and gained 15.6% of yield. Based on the results of phytochemical test, secondary metabolites compound that contained in bark kecapi are alkaloid, flavonoid, triterpenoid, steroid, phenolic and saponin. On antihiperkolesterolemia activity test by using male mice, there are several treatments that negative control (-), positive control (+) and three treatment with different doses i.e. a low doses (9.5 mg/kg BB), middle doses (19 mg/kg BB) and high doses (38 mg/kg BB). The parameter measured was blood serum of male mice by using a Cholesterol Test Strips. From this test it showed that the effectiveness of decreased total cholesterol level doses of 19 mg/kg BB showed total cholesterol level under 100 mg/dL.

Keywords:      Leaf kecapi (Sandoricum koetjape (Burm.f.) Merr.), Phytochemicals test, Total cholesterol levels, Cholesterol test strips.

Downloads

Download data is not yet available.

References

Murray, Granner, dan Rodwell. 2003. Biokimia Harper. Jakarta: Penerbit Buku Kedokteran EGC.

Ngili, Y. 2010. Biokimia Dasar. Bandung : Rekayasa Sains.

Hoffman, Matthew, dkk. 1996. Bebas dari Penyakit. Jakarta : PT. Gramedia Pustaka Utama.

Sihombing, A.B.H. 2003.Pemanfaatan Rumput Laut sebagai Sumber Serat Pangan dalam Ransum untuk Menurunkan Kolesterol Darah Tikus Percobaan. Fakultas Teknologi Pertanian, IPB. Bogor.

Sukmono, R. Joko, SH. 2009. Mengatasi Aneka Penyakit Dengan Terapi Herbal.Jakarta : Agromedia Pustaka.

Ismail, I.S., Ito, H., Hatano, T., Taniguchi, S. and Yoshida, T. 2003.Modified limonoids from the leaves of Sandoricum koetjape.Phytochemistry, 64, 1345-1349.

Warsinah, 2011.Identifikasi Senyawa Antifungi dari Kulit Batang Kecapi (Sandoricum koetjape) dan Aktivitasnya Terhadap Candida albicans. Majalah Obat Tradisional, 16(3), 165 – 173. Jurnal Penelitian. Purwokerto : Universitas Jenderal Soedirman.

Djumidi, H. 1997.Invertaris Tanaman Obat Indonesia Jilid IV.Badan Penelitian dan Pengembangan Kesehatan, Departemen Kesehatan dan kesejahteraan Sosial RI. Jakarta.

Hedges L. J, C. E. Lister. 2007. The Nutritional Attributes of Allium Species. Crop and Food Research Confidential Report. No. 1814.
Published
2016-06-14
How to Cite
KARTIKA, Rudi. Pengaruh Pemberian Ekstrak Etanol Daun Kecapi (Sandoricum koetjape (Burm.f.) Merr.) Terhadap Penurunan Kadar Kolesterol Total pada Mencit Jantan (Mus musculus). JURNAL KIMIA MULAWARMAN, [S.l.], v. 13, n. 2, june 2016. ISSN 2476-9258. Available at: <http://jurnal.kimia.fmipa.unmul.ac.id/index.php/JKM/article/view/200>. Date accessed: 04 july 2022.
Section
Artikel