REVIEW KANDUNGAN METABOLIT SEKUNDER BEBERAPA TUMBUHAN UNCARIA YANG TERDAPAT DI KALIMANTAN TIMUR

  • Erwin - Department of Chemistry, Faculty of Mathematics and Natural Sciences, Mulawarman University

Abstract

Uncaria is a plant genus that is distributed mainly in tropical and subtropical areas. About 38 Uncaria species grow in the Asia Pacific region. Based on a literature study, it was found that five Uncaria species in the tropical rain forests of East Kalimantan. Several species of Uncaria have long been known and used in traditional medicine such as treating asthma, cancer, diabetes, rheumatism, neurodegenerative diseases, mouth sores, diarrhea and dysentery, sore throat, and gums. The content of secondary metabolites includes flavonoids, polyphenols, terpenoids, alkaloids, iridoids, and coumarin.

Keyword
Tropical, Uncaria, Traditional Medicine, Secondary Metabolites

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References

[1] Ridsdale C. E. 1978. A revision of Mitragyna and Uncaria (Rubiaceae). Blumea. 24:43–100.
[2] Turner I. M. 2018. A revised conspectus of Uncaria (Rubiaceae). Journal of Plant Taxonomy and Geography. 73(1):9–21.
[3] Zhang Q., Zhao J. J., Xu, J., Feng F., Qu W. 2015. Medicinal uses, phytochemistry and pharmacology of the genus Uncaria. Journal of Ethnopharmacology. 173:48-80.
[4] Nursanti, Novriyanti, dan Wulan C. 2018. Various types of potential drug plants in Muhammad Sabki Urban Forest Jambi city. Media Konservasi. 23(2):169-177.
[5] Mukhlisi, Atmoko T., Yassir I., Setiawan R. and Kusuma A. R. 2017. Abundance and nutrient content of some food plants in Sumatran rhino habitat in the forest of Kutai Barat, East Kalimantan, Indonesia. Pachyderm. 58:77-87.
[6] Ahmad R., Hashim H. M., Noor Z. M., Ismail N. H., Salim F., Lajis N. H., Shaari K. 2011. Antioxidant and antidiabetic potential of Malaysian Uncaria. Research Journal of Medicinal Plant. p 1-9
[7] Rahmawati N., Utami R., dan Azwendah. 2015. Cytotoxic activity of akar kaik kaik extract (Uncaria cordata Lour.) Merr of Artemia salina Leach. Prosiding Seminar Nasional & Workshop “Perkembangan Terkini Sains Farmasi & Klinik, P a d a n g , 6-7 November 2015, 324-329.
[8] Rahmawati N., Utami R. dan Azwendah 2016. Isolasi dan uji aktivitas sitotoksik senyawa murni dari ekstrak etil asetat daun tumbuhan akar kaik-kaik Uncaria cordata (Lour.) Merr. Scienta. 6(2):122-126.
[9] Abdullah N. H., Salim F., and Ahmad R. 2016. Isolation of flavonols from the Sems of Malaysian Uncaria cordata var. ferruginea (BLUME) RIDSD. Malaysian Journal of Analytical Sciences. 20(4):844– 848.
[10] Abdullah N. H., Salim F., and Ahmad R. 2016. Chemical constituents of Malaysian U. cordata var. ferruginea and their in vitro α-glucosidase inhibitory activities. Molecules. 21(525):1-11.
[11] NCATS Inxight: drugs. 2018. https://drugs.ncats.io, diakses tanggal diakses tanggal 29 Februari 2020.
[12] Tan S. Y., Koh C. Y., Siow H. J. M., Li T., Wong H. F., Heyzer A. and Tan H. T. W. 2013. 100 Common vascular plants of the Nee Soon Swamp Forest, Singapura, Raffles Museum of Biodiversity Research National University of Singapore, 241-242
[13] Salim F., Yusri Yunus, Y.M., Anouar El. H., Awang K., Langat M., Cordell G. A., and Ahmad R. 2019. Absolute configuration of alkaloids from Uncaria longiflora through experimental and computational approaches. J. Nat. Prod. 82(11):2933-2940.
[14] Natasya M. 2018. Bikin penasaran, ternyata Tanaman Bajakah Banyak Jenisnya. detikHealth, https://health.detik.com/berita-detikhealth/d-4664000/bikin-penasaran-ternyata-tanaman-bajakah-banyak-jenisnya, diakses tanggal 29 Februari 2020.
[15] Hilmi H. L. dan Rahayu R. 2018. Artikel tinjauan: Aktivitas dan farmakologi gambir (Uncaria Gambir ROXB.). Farmaka Suplemen. 16(2):134-141.
[16] Nainggolan P., Paqrhusip D. dan Sebayang L. 2013. Teknologi Tanaman Gambir. Balai Teknologi Pertanian Sumatera Utara, Medan.
[17] Warnida H., Masliyana A. dan Sapri. 2016. Formulasi ekstrak etanol gambir (Uncaria gambir Roxb.) dalam bedak anti jerawat. Jurnal Ilmiah Manuntung. 2(1):99-106.
[18] Irfan, Rochmah S. R., Yusuf M., Aditya G. 2015. Efektifitas daun gambir (Uncaria gambir Roxb) untuk menurunkan halitosis yang disebabkan oleh plak. ODONTO Dental Journal. 2(2):52-56.
[19] Sazwi N. N., Nalina T. & Rahim Z. H. A., 2013. Antioxidant and cytoprotective activities of Piper betle, Areca catechu, Uncaria gambir and betel quid with and without calcium hydroxide. BMC Complementary and Alternative Medicine. 13(1):351-363.
[20] Amir M. et al. 2012. Phytochemical analysis and in vitro antioxidant activity of Uncaria gambir. International Journal of Green Pharmacy. 6:67-72.
[21] Anggraini T., Tai A., Yoshino T. & Itani T. 2011. Antioxidative activity and catechin content of four kinds of Uncaria gambir extracts from West Sumatra, Indonesia. African Journal of Biochemistry Research. 5(1):33-38.
[22] Kassim M. J. Hussin M. H., Achmad A., Dahon N. H., Suan T. K., and Hamdan H.S. 2011. Determination of total phenol, condensed tannin and flavonoid contents and antioxidant activity of Uncaria gambir extracts. Majalah Farmasi Indonesia. 22(1):50-59.
[23] Aditya M. dan Ariyanti P. R. 2016. Manfaat gambir (Uncaria gambir Roxb) sebagai antioksidan. Majority. 5(3):129-133.
[24] Melia S., Novia D. and Juliyarsi I. 2015. Antioxidant and antimicrobial activities of gambir (Uncaria gambir Roxb) extracts and their application in rendang. Pakistan Journal of Nutrition. 14(12):938-941.
[25] Musdja M. Y., Hapsaria M. A. & Agusta A. 2017. Comparison of activity and inhibitory mechanism between (+)-catechin and water extract of gambir (Uncaria Gambir Roxb.) against some bacteria. Sciences and Engineering. 4(2):55-60.
[26] Yunarto N., Berna E. B., and Laurentia K. L. 2015. Potency of ethyl acetate fraction of gambier leaves extract (Uncaria gambir Roxb.) as antihyperlipidemia. Jurnal Kefarmasian Indonesia. 5(1):1-10.
[27] Zebua E. A., Silalahi J. & Julianti E. 2018. Hypoglicemic activity of gambir (Uncaria gambir Robx.) drinks in alloxan-induced mice. Earth and Environmental Science. 122.
[28] Kim T. H., 2016. A novel a-glucosidase inhibitory constituent from Uncaria gambir. J Nat Med. 70(4):811-815.
[29] Apea-Bah F. B. et al. 2009. Assessment of the DPPH and alpha-glucosidase inhibitory potential of gambir and qualitative identification of major bioactive compound. Journal of Medicinal Plants Research. 3(10):736-757.
[30] Rismana E., Ningsih S., dan Fachrudin F. 2017. In vitro study of xanthine oxidase inhibitory of gambir (Uncaria gambir) Hunter Roxb extracts. Pharmacognosy Journal. 9(6):862-865.
[31] Ningsih S., Fachrudin F., Rismawa E., Purwaningsih E. H., Sumaryono W., Jusman S.W. 2014. Evaluation of antilipid peroxidation activity of gambir extract on liver homogenat in vitro. Int. J. PharmTech Res. 6(3):982-989.
[32] Dewi S. R. P., Marlamsya D. O., Bikarindrasari R. 2017. Efek antikaries ekstrak gambir pada tikus jantan galur wistar. Majalah Kedokteran Gigi Indonesia. 3(2):83-92.
[33] Patil S. H., Deshmukh P. V., Sreenivas S. A., Sankeertana V., Rekha V., and Anjaiah B. 2012. Evaluation of anthelmintic activity of Uncaria gambir Roxb. against Pheretima posthuma. Int. J. Drug Dev & Res. 4(4):234-238.
[34] Maulina S., Pratiwi D. R., Erwin. 2019. Phytochemical screening dan bioactivity of root extract of Uncaria nervosa Elmer (Bajakah). Jurnal Atomik. 4(2):100-102.
[35] Meyer B. N. Ferrigni N. R. Putnam J. E. Jacobsen L. B. Nichols D. E., McLaughlin J. L. 1982. Brine shrimp: a convenient general bioassay for active plant constituents. Planta Med. 45(5):31-34.
[36] Valerio L. G., Gonzales G. 2005. Toxicological aspects of the south american herbs cat's claw (Uncaria tomentosa) and maca (Lepidium meyenii): A critical synopsis. Toxicological Reviews. 24:11–35.
[37] Iskandar D. 2020. Aplikasi uji skrining fitokimia terhadap daun Uncaria tomentosa sebagai bahan utama dalam pembuatan teh, Jurnal Teknologi Technoscientia. 2(2):153-158.
[38] Shen J., Shalom J., Cock I. E. 2018. The Antiproliferative properties of Uncaria tomentosa Willd. DC extracts against caco2 and HeLa cancer cell lines. Pharmacogn. Commn. 8(1):8-14.
[39] Warsidah, Fadly D., Bohari. 2020, Antibacterial and anti-inflammatory activities of ethanol extract obtained from the hooks of Uncaria tomentosa (Wild. Ex Schult) DC originated Kalimantan, Indonesia. Sys Rev Pharm. 11(7):65-70.
[40] Dreifuss A. A., Pereira A. L. B., Avila T. V., Soley B. da. S., Rivero A. J., Aguilar J. L., Acco A. 2010. Antitumoral and antioxidant effects of a hydroalcoholic extract of cat’s claw (Uncaria tomentosa) (Willd. Ex Roem. & Schult) in an in vivo carcinosarcoma model. Journal of Ethnopharmacology. 130:127–133.
[41] Dreifuss A. A., Pereira A. L. B., Fabossi I. A., Lı´vero F. A. D. R., Stolf A. M., de Souza C. E. A., Gomes L. D. O., Constantin R. P., Furman A. E. F., Strapasson R. L. B., Teixeira S., Aleksander A. R., Muscara M. N., Stefanello M. E. A., Acco A. 2013. Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumour by modulating oxidative stress and not by alkaloid activity. PLoS ONE. 8(2):1-14.
Published
2020-09-28
How to Cite
-, Erwin. REVIEW KANDUNGAN METABOLIT SEKUNDER BEBERAPA TUMBUHAN UNCARIA YANG TERDAPAT DI KALIMANTAN TIMUR. JURNAL ATOMIK, [S.l.], v. 5, n. 1, p. 18-24, sep. 2020. ISSN 2549-0052. Available at: <http://jurnal.kimia.fmipa.unmul.ac.id/index.php/JA/article/view/940>. Date accessed: 31 oct. 2020.
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