AKTIVITAS ANTIMALARIA SENYAWA FLAVANON TERISOPRENILASI DARI KULIT BATANG Erythrina fusca L.

  • Novi Fatmawati Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga
  • Novi Anggreini Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga
  • Ratih Dewi Saputri Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga
  • Tjitjik Srie Tjahjandarie Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga
  • Mulyadi Tanjung Universitas Airlangga

Abstract

Two isoprenylated flavanones  namely as lonchocarpol A (1)  dan lupinifolin (2) were isolated from  the stem bark of Limonia accidissima L. Erythrina fusca L. Their structures were determined  based on spectroscopic data such as UV, IR, MS and NMR. Compounds 12 were evaluated for their antimalarial against Plasmodium falciparum strain 3D7 showing their IC50 were 1.18 and 0.8 µg/ml, respectively and very high activity.


 

Keyword
Erythrina fusca L., lonchocarpol A, lupinifolin, antimalaria

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References

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Published
2018-11-29
How to Cite
FATMAWATI, Novi et al. AKTIVITAS ANTIMALARIA SENYAWA FLAVANON TERISOPRENILASI DARI KULIT BATANG Erythrina fusca L.. JURNAL KIMIA MULAWARMAN, [S.l.], v. 16, n. 1, p. 36-41, nov. 2018. ISSN 2476-9258. Available at: <http://jurnal.kimia.fmipa.unmul.ac.id/index.php/JKM/article/view/586>. Date accessed: 26 apr. 2019. doi: https://doi.org/10.30872/jkm.v16i1.586.
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