AKTIVITAS ANTIMALARIA SENYAWA FLAVANON TERISOPRENILASI DARI KULIT BATANG Erythrina fusca L.
Abstract
Two isoprenylated flavanones namely as lonchocarpol A (1) dan lupinifolin (2) were isolated from the stem bark of Limonia accidissima L. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antimalarial against Plasmodium falciparum strain 3D7 showing their IC50 were 1.18 and 0.8 µg/ml, respectively and very high activity.
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[2]Tjahjandarie, T.S., Pudjiastuti, P., Saputri, R.D., Tanjung, M., (2014). Antimalaria and antioxidant activity of phenolic compounds isolated from Erythrina crysta-galli L. J. Chem. Pharm. Res. 6, 786–790.
[3]Innok, P., Rukachaisirikul, T., Suksamrarn, A., (2009), Flavanoids and pterocarpans from the bark of Erythrina fusca, Chem. Pharm. Bull, 57(9), 993-996.
[4]Khaomek, P., Ichino, C., Ishiyama, A., Sekiguchi, H., Namatame, M., Ruangrungsi, N., Saifah, E., Kiyohara, H., Otoguro, K., Omura, S., Yamada, H., (2008), In vitro antimalarial activity of prenylated flavonoids from Erythrina fusca, J. Nat Med, 62, 217-220.
[5]Tjahjandarie, T.S., Tanjung, M., (2015). Phenolic compounds from the stem bark of Erythrina orientalis and their cytotoxic and antioxidant activities. Der Pharma Chem, 7(1), 206-211.
[6]Tanjung, M., Saputri, R.D., Tjahjandarie, T.S., (2017). 4-Methoxy-3-(3-methylbut-2-en-1-yl)-7-((3-methylbut-2-en-1-yl)oxy) quinolin-2(1H)-one from Melicope moluccana T.G. Hartley. Molbank. M939. 2, 1-5.
[7]Tjahjandarie, T.S., Tanjung, M., (2015). Lead compound antimalaria dan antioksidan senyawa alkaloid, flavonoid, dan kumarin dari Limonia accidisima L.. Laporan Akhir Penelitian Unggulan Perguruan Tinggi, Universitas Airlangga. 1-45.
[8]Tanjung, M., Saputri, R.D., Tjahjandarie, T.S., (2016). Antimalarial and antioxidant of isoprenylated coumarins from the stem bark of Mesua borneensis L.. J Biol Active Prod from Nature. 6, 95-100.
[9]Marliana, E., Tjahjandarie, T.S., Tanjung, M., (2015). Isoprenylated flavanone derivatives from Macaranga hosei King ex Hook F. Der Pharmacia Lettre. 7(3), 153-156.
[10]Tanjung M, Mujahidin D, Hakim EH, Darmawan A, Syah Y.M. (2010). Geranylated flavonols from Macaranga rhizinoides. Nat Prod Commun. 5,1209-1211.
[11]Marliana, E., Tjahjandarie, T.S., Tanjung, M., (2016). Aktivitas antioksidan senyawa flavonoid dari Macaranga pearsonii Merr. J. Kimia Mulawarman. 13(2), 97-100.
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