Antioxidant and Antimalarial Activities of Phenolic Compounds from Leaves of Macaranga beccariana Merr.

  • Eva Marliana Jurusan Kimia FMIPA UNMUL
  • Chairul Saleh Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Mulawarman
  • Medi Hendra Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Mulawarman

Abstract

Macaranga beccariana Merr. is an endemic plant of Kalimantan which is no report yet about its biological activity and isolated compounds. Therefore, in order to know the potency of M. beccariana, determination of antioxidant and antimalarial activities along with isolation of bioactive compounds from this plant must be carried out. In this research, the leaves of M. beccariana was extracted using methanol to obtain methanol extract. Furthermore, the extract was separated and purified to obtain compound 1 and compound 2. Based on structure elucidation using spectrometer analysis including UV, 1H and 13C NMR, compounds 1 and 2 which belong to phenolics were identified as 4-hidroxybenzoic acid and 3,4-dihidroxybenzoic acid, respectively. Moreover, antioxidant activity using DPPH (2,2-diphenyl-1-picrylhydrazyl) and antimalarial activity towards Plasmodium falciparum strain 3D7 using Giemsa staining were performed. Rutine and chloroquine difosfat were used as positive controls for antioxidant and antimalarial, respectively. The results showed that the methanol extract of M. beccariana and its isolated compounds (1 and 2) are active for those activities. It can be concluded that the leaves of M. beccariana has good potency as antioxidant and antimalarial agents.

Keyword
Macaranga beccariana Merr., 4-hidroxybenzoic acid, 3,4-dihidroxybenzoic acid, antioxidant, antimalarial

Downloads

Download data is not yet available.

References

[1] Trigg, P. I. & Kondrachine, A.V. (1998). The current global malaria situation, in Irwin W. Sherman, Malaria Parasite Biology, Phatogenesis and Protection. ASM Press, Washington DC, 11-22.
[2] Wilcox, M., Bodeker, G., & Rasoanoivo, P. (2004), Traditional medical plants and malaria. CRC Press, London, 35-68.
[3] Marliana, E. (2016). Hubungan struktur senyawa flavonoid macaranga kalimantan terhadap aktivitas antioksidan dan aktivitas antiplasmodial. Disertasi, Universitas Airlangga, 63-80.
[4] Phommart, S., Sutthivaiyakit, P., Chimnoi, N., Ruchirawat, S., & Sutthivaiyakit, S. (2005). Constituents of the leaves of Macaranga tanarius. J. Nat. Prod., 68, 927-930.
[5] Sutthivaiyakit, S., Unganont, S., Sutthivaiyakit, P., & Suksamrarn, A. (2002). Diterpenylated and prenylated flavonoids from Macaranga denticulata. J. Tetrahedron, 58, 3619-3622.
[6] Marliana E, Tjahtjandarie T. S, & Tanjung M., 2015, Isoprenylated flavanone derivatives from Macaranga hosei King ex Hook F. Der Pharmacia Lettre, 7(3), 153–156.
[7] Zakaria, I., Ahmat, N., Jaafar, F. M., & Widyawaruyanti, A. (2012). Flavonoids with antiplasmodial and cytotoxic activities of Macaranga triloba. J. Fitoterapia, 83, 968-972.
[8] Slik, J. W. F., Priyono, & Welzen, V. P. C. (2000). Key to the Macaranga thou. and Mallotus lour. species (Euphorbiaceae) of East Kalimantan, Indonesia. Garden’s Bulletin Singapore, 52, 11-87.
[9] Kadoma, Y. & Seiichiro, F. (2011). Radical-scavenging activity of dietary phytophenols in combination with co-antioxidants using the induction period method. Journal of Molecules, 16, 10457-10470.
[10] Diallo, D., Maiga, A., Diakite, C., & Merlin,W. (2004), Malarial-5 : Development of an antimalarial phytomedicine in Mali. CRC Press LLC, 1-14.
[11] Mabry, T. J. & Markham, K. R. (1970). Flavonoids: The systematic identification of flavonoid. Springer-Verlag, New York,.35-61.
[12] Tanjung, M., Mujahidin, D., Hakim, E. H., Darmawan, & Syah, Y. M. (2010). Geranylated flavonols from Macaranga rhizinoides. Journal Natural Product Communications, 5(8),1209-1211.
[13] Tanjung, M., Hakim, E. H., Elfahmi, Latip, J. M., & Syah, Y. M. (2012). Dihidroflavonol and flavonol derivatives from Macaranga recurvata. Journal Natural Product Communications, 7(10),1309-1310.
[14] Lisdawati, V. & Kardono, L. B. S. (2006). Aktivitas antioksidan dari berbagai fraksi ekstrak daging buah dan kulit biji Mahkota Dewa (Phaleria macrocarpa). Media Litbang Kesehatan, XVI(4),1-7.
[15] Muharni, Elfita, & Amanda. (2013). Aktivitas antioksidan senyawa (+) Morelloflavon dari kulit batang tumbuhan Gamboge (Garcinia xanthochymus). Prosiding Semirata FMIPA, Universitas Lampung, Lampung, 265-268.
[16] Kohler, I., Siemsa, K. J., Siems, K., Herna’ndez, Ibarra, R. A., Berendsohn, W. G., Bienzle, U., &Eich, E. (2002). In vitro antiplasmodial investigation of medicinal plants from El Salvador. Verlag der Zeitschrift für Naturforschung Tübingen, 57c, 277-281.
Published
2018-05-30
How to Cite
MARLIANA, Eva; SALEH, Chairul; HENDRA, Medi. Antioxidant and Antimalarial Activities of Phenolic Compounds from Leaves of Macaranga beccariana Merr.. JURNAL KIMIA MULAWARMAN, [S.l.], v. 15, n. 2, p. 106-110, may 2018. ISSN 2476-9258. Available at: <http://jurnal.kimia.fmipa.unmul.ac.id/index.php/JKM/article/view/611>. Date accessed: 18 aug. 2018. doi: https://doi.org/10.30872/jkm.v15i2.611.
Section
Artikel